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Year Number of Results
1993 1
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1996 4
1997 3
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2000 2
2001 4
2002 4
2003 2
2004 2
2005 3
2006 4
2007 3
2008 2
2009 2
2010 1
2011 1
2012 3
2013 2
2014 2
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2016 4
2017 2
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2019 6
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83 results

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Page 1
FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease.
Garcia-Recio S, Thennavan A, East MP, Parker JS, Cejalvo JM, Garay JP, Hollern DP, He X, Mott KR, Galván P, Fan C, Selitsky SR, Coffey AR, Marron D, Brasó-Maristany F, Burgués O, Albanell J, Rojo F, Lluch A, de Dueñas EM, Rosen JM, Johnson GL, Carey LA, Prat A, Perou CM. Garcia-Recio S, et al. J Clin Invest. 2020 Sep 1;130(9):4871-4887. doi: 10.1172/JCI130323. J Clin Invest. 2020. PMID: 32573490 Free PMC article.
Finally, multivariate analysis demonstrated that the FGFR4-induced signature also predicted site-specific metastasis for lung, liver, and brain, but not for bone or lymph nodes. These data identify a link between FGFR4-regulated genes and metastasis, suggesti …
Finally, multivariate analysis demonstrated that the FGFR4-induced signature also predicted site-specific metastasis for lung, liver, …
The Klotho proteins in health and disease.
Kuro-O M. Kuro-O M. Nat Rev Nephrol. 2019 Jan;15(1):27-44. doi: 10.1038/s41581-018-0078-3. Nat Rev Nephrol. 2019. PMID: 30455427 Review.
FGF19 is a satiety hormone that is secreted from the intestine on ingestion of food and binds the betaKlotho-FGFR4 complex in hepatocytes to promote metabolic responses to feeding. ...
FGF19 is a satiety hormone that is secreted from the intestine on ingestion of food and binds the betaKlotho-FGFR4 complex in hepatoc …
Multiple functions of autophagy in vascular calcification.
Zhou X, Xu SN, Yuan ST, Lei X, Sun X, Xing L, Li HJ, He CX, Qin W, Zhao D, Li PQ, Moharomd E, Xu X, Cao HL. Zhou X, et al. Cell Biosci. 2021 Aug 16;11(1):159. doi: 10.1186/s13578-021-00639-9. Cell Biosci. 2021. PMID: 34399835 Free PMC article. Review.
Furthermore, autophagy also promotes vitamin K2-induced MC3T3 E1 osteoblast differentiation and FGFR4/FGF18- and JNK/complex VPS34-beclin-1-related bone mineralization via vascular calcification. ...
Furthermore, autophagy also promotes vitamin K2-induced MC3T3 E1 osteoblast differentiation and FGFR4/FGF18- and JNK/complex VPS34-be …
Structural basis for FGF hormone signalling.
Chen L, Fu L, Sun J, Huang Z, Fang M, Zinkle A, Liu X, Lu J, Pan Z, Wang Y, Liang G, Li X, Chen G, Mohammadi M. Chen L, et al. Nature. 2023 Jun;618(7966):862-870. doi: 10.1038/s41586-023-06155-9. Epub 2023 Jun 7. Nature. 2023. PMID: 37286607 Free PMC article.
To reveal the molecular mechanism underpinning the coreceptor role of HS, we solved cryo-electron microscopy structures of three distinct 1:2:1:1 FGF23-FGFR-alphaKlotho-HS quaternary complexes featuring the 'c' splice isoforms of FGFR1 (FGFR1c), FGFR3 (FGFR3c) or FGFR4 as …
To reveal the molecular mechanism underpinning the coreceptor role of HS, we solved cryo-electron microscopy structures of three distinct 1: …
FGF20.
Van Greenen JD, Hockman D. Van Greenen JD, et al. Differentiation. 2023 Nov 7:100737. doi: 10.1016/j.diff.2023.10.005. Online ahead of print. Differentiation. 2023. PMID: 38007375 Free article.
It was first identified in Xenopus embryos and was isolated shortly thereafter from the adult rat brain. Its receptors include FGFR4, FGFR3b, FGFR2b and the FGFRc splice forms. In adults it is highly expressed in the brain, while it is expressed in a variety …
It was first identified in Xenopus embryos and was isolated shortly thereafter from the adult rat brain. Its receptors include FGF …
P-glycoprotein (ABCB1/MDR1) limits brain accumulation and Cytochrome P450-3A (CYP3A) restricts oral availability of the novel FGFR4 inhibitor fisogatinib (BLU-554).
Li W, Sparidans R, El-Lari M, Wang Y, Lebre MC, Beijnen JH, Schinkel AH. Li W, et al. Int J Pharm. 2020 Jan 5;573:118842. doi: 10.1016/j.ijpharm.2019.118842. Epub 2019 Nov 20. Int J Pharm. 2020. PMID: 31759109
Fisogatinib (BLU-554) is a highly selective and potent oral fibroblast growth factor receptor 4 (FGFR4) inhibitor currently in Phase I clinical trials for treatment of hepatocellular carcinoma (HCC). ...However, the relative tissue distribution of fisogatinib remained unal …
Fisogatinib (BLU-554) is a highly selective and potent oral fibroblast growth factor receptor 4 (FGFR4) inhibitor currently in Phase …
Thyroid Hormones Regulate Goblet Cell Differentiation and Fgf19-Fgfr4 Signaling.
Blitz E, Matsuda H, Guenther S, Morikawa T, Kubota Y, Zada D, Lerer-Goldshtein T, Stainier DYR, Appelbaum L. Blitz E, et al. Endocrinology. 2021 May 1;162(5):bqab047. doi: 10.1210/endocr/bqab047. Endocrinology. 2021. PMID: 33675223
Notably, the expression of genes encoding to Fgf19 and its receptor Fgfr4 was markedly increased in the intestine of hypothyroid adults, and treatment with T3 normalized it. ...Both the TH and Fgf19-Fgfr4 signaling pathways can be pharmaceutical targets for the trea …
Notably, the expression of genes encoding to Fgf19 and its receptor Fgfr4 was markedly increased in the intestine of hypothyroid adul …
Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits.
Chen J, Poskanzer KE, Freeman MR, Monk KR. Chen J, et al. Nat Neurosci. 2020 Oct;23(10):1297-1306. doi: 10.1038/s41593-020-0703-x. Epub 2020 Sep 7. Nat Neurosci. 2020. PMID: 32895565 Free PMC article.
Finally, using a cell-specific CRISPR-Cas9 approach, we demonstrate that fgfr3 and fgfr4 are required for vertebrate astrocyte morphogenesis. This work provides the first visualization of astrocyte morphogenesis from stem cell to post-mitotic astrocyte in vivo, identifies …
Finally, using a cell-specific CRISPR-Cas9 approach, we demonstrate that fgfr3 and fgfr4 are required for vertebrate astrocyte morpho …
FGFR4-driven plasticity in breast cancer progression and resistance to therapy.
Braun M, Piasecka D, Sadej R, Romanska HM. Braun M, et al. Br J Cancer. 2024 Apr 17. doi: 10.1038/s41416-024-02658-y. Online ahead of print. Br J Cancer. 2024. PMID: 38627607 Review.
More importantly, FGFR4 is also emerging as a potential driver of BCa intrinsic subtype switching, and an essential promoter of brain metastases, particularly in the HER2-positive BCa. ...We also discuss a potential clinical benefit of targeting FGFR4 in the …
More importantly, FGFR4 is also emerging as a potential driver of BCa intrinsic subtype switching, and an essential promoter of br …
Role of Fibroblast Growth Factors Receptors (FGFRs) in Brain Tumors, Focus on Astrocytoma and Glioblastoma.
Ardizzone A, Scuderi SA, Giuffrida D, Colarossi C, Puglisi C, Campolo M, Cuzzocrea S, Esposito E, Paterniti I. Ardizzone A, et al. Cancers (Basel). 2020 Dec 18;12(12):3825. doi: 10.3390/cancers12123825. Cancers (Basel). 2020. PMID: 33352931 Free PMC article. Review.
FGFRs are subjected to multiple somatic aberrations such as chromosomal amplification of FGFR1; mutations and multiple dysregulations of FGFR2; and mutations, translocations, and significant amplifications of FGFR3 and FGFR4 that correlate to oncogenesis process. Therefore …
FGFRs are subjected to multiple somatic aberrations such as chromosomal amplification of FGFR1; mutations and multiple dysregulations of FGF …
83 results